Lepto incidence is at least 8%, based on research reported in the Journal of the AVMA. 33,000+ dogs were tested from all over the US.1 And regardless of the area — metro, suburban or rural — transmission can occur when a dog spends just a few minutes outside.

    Plus, the number of potential carriers and places where infection can occur is in the billions.

    That's a big risk. But there's an easy solution. It's Duramune® Max 5/4L with SubUnit4 Purification™ designed for added safety and a smooth injection.

    1Gautam R, Wu CC, Guptil LF, et al. Detection of antibodies against Leptospira serovars via microscopic agglutination tests in dogs in the United States, 2000-2007. J Am vet Med Assoc. 2010;237 (3):293-298

    Squirrels

    Population
    • Estimated U.S. population of 1 billion 
    Where to find them
    • Where don't you find them?
    • Rural, suburban and metro areas 
    How they are risk factors
    • Can spread infection widely 
    • Big contributor to suburban lepto incidence rate
    Risk Indicator
    • High

    Pigs

    Population
    • Estimated U.S. population of 70 million
    Where to find them
    • Farms around the world 
    • Nursery rhymes and kids songs 
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass
    Risk Indicator
    • Low/Medium

    Cattle

    Population
    • Estimated U.S. population of 91 million 
    Where to find them
    • Farms, feedlots and dairies — and right behind you!
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass
    Risk Indicator
    • Medium

    Skunks

    Population
    • We're too scared of them to count
    Where to find them
    • Rural areas and near water sources
    • Some suburbs and semi-rural areas
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass
    Risk Indicator
    • Medium/High

    Rats

    Population
    • Estimated U.S. population of 313 million
    Where to find them
    • Pretty much anywhere people live and work
    How they are risk factors
    • By urinating almost anywhere they go (which is nearly everywhere)
    Risk Indicator
    • High

    Horses

    Population
    • Estimated U.S. population of 7.3 million
    Where to find them
    • Farms, pastures and the occasional parade
    How they are risk factors
    • Can spread lepto by urinating in puddles, grass or in front of an unlucky marching band
    Risk Indicator
    • Medium

    Raccoons

    Population
    • Up to 400 can occupy one square mile in the U.S.
    Where to find them
    • Rural, urban and suburban areas
    • Backyards everywhere
    How they are risk factors
    • Can spread lepto by urinating in puddles, on lawns or in your house (if they're crafty)
    Risk Indicator
    • High

    Soil and Water

    Population
    • In the U.S., there are 2.3 billion acres of land and 1.7 million acres of water
    Where to find them
    • Wherever you happen to be standing at the moment
    How they are risk factors
    • Lepto-infected critter urine can be found on grass, in puddles and virtually anywhere
    Risk Indicator
    • Medium/High

    Deer

    Population
    • Estimated U.S. population of 20 million and growing
    Where to find them
    • Forests, parks, even suburban backyards
    • Called the new "rat" of urban green areas
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass and lawns
    Risk Indicator
    • Medium/High

    Foxes

    Population
    • They're almost too sneaky to count, but populations are growing in many U.S. states
    Where to find them
    • Rural areas, but many are moving into suburbs (where they're not good neighbors)
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass
    Risk Indicator
    • Medium

    Coyotes

    Population
    • U.S. populations remain steady. For example, an estimated 30,000 live in Illinois
    Where to find them
    • Rural areas with growing numbers in cities like Chicago, where over 300 are caught yearly
    How they are risk factors
    • Can spread lepto by urinating in puddles and on grass
    Risk Indicator
    • Low/Medium

    Subunit4 Purification™ for a Smooth Injection

    We treat the immunogens we use with an industry-exclusive, four-part purification process that removes cellular debris for a smooth injection.

    Four steps to purified immunogens:

    Proven Safe Inside the Lab and Out

    We demonstrated Duramune® Max 5/4L's safety in the largest real-world safety study ever conducted on canine vaccines.2 During the study:

    • Duramune® Max 5/4L showed a low incidence of vaccine-associated adverse events (VAAEs) 
    • Nearly 30,000 doses of Duramune® Max 5/4L were administered to dogs in the real-world clinical settings
    • Fewer than three VAAEs appeared per 1,000 dogs vaccinated with Duramune® Max 5/4L
    2JAVMA. 2005;227(7):1102-1108.Moore GE, Guptill LF, Ward MP, et al. Adverse events diagnosed within three days of vaccine administration in dogs.

    Get Efficacy You Can Trust

    Duramune® Max 5/4L protects against all four serovars responsible for lepto infection in the United States. This includes today's most common lepto causes, grippotyphosa and pomona.

    Plus, Duramune® Max 5/4L offers a proven track record, with more than 128 million lepto vaccine doses sold since 1986 -- more than any other manufacturer.3

    3 Data on File.

    INTRODUCING

    ULTRA™ DURAMUNE® VACCINES FOR LEPTO PROTECTION.

    This first and only line of 0.5 mL vaccines is designed for a more comfortable injection with 50% less volume, but with the same protection that has made Duramune a trusted brand for 30 years.